Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (from 405 mg Zinc Gluconate)
50 mg
455%

Top Medical Research Studies

7
Zinc's role in kidney stones
We investigated how different forms of zinc intake—dietary, supplemental, and serum levels—might connect to the prevalence of kidney stones in adults. By analyzing data from the National Health and Nutrition Examination Survey (NHANES) collected over nearly a decade, we uncovered some interesting patterns.

Our findings revealed that dietary zinc intake appeared to be linked to a lower likelihood of developing kidney stones. In fact, for every increase in daily zinc intake, the odds of having kidney stones decreased. We noted that this relationship was particularly strong among women and individuals who were classified as overweight or obese.

Interestingly, while dietary zinc and serum zinc levels were inversely associated with kidney stones, we found no significant connection with supplemental zinc intake. This suggests that getting zinc from food sources may be more beneficial for kidney stone prevention than taking zinc supplements.

Overall, while our analysis highlights a potential protective effect of dietary zinc and serum zinc levels against kidney stones, it also points out the need for more thorough research to fully understand these relationships.
Read More
We examined the link between dietary zinc intake and the occurrence of calcium kidney stones among adolescents. To do this, we conducted a nested case-control study involving 30 teenagers aged 12 to 18 who had their first calcium-based kidney stone and matched them with 30 healthy controls based on age, sex, race, and enrollment month.

What we found was quite revealing. The teenagers who developed kidney stones were consuming less daily zinc—around 8.1 mg—compared to their healthy counterparts, who averaged 10 mg. Furthermore, the intake for both boys and girls in the kidney stone group fell below the recommended levels set by health authorities. Even more interestingly, we discovered that for every additional 1 mg of zinc consumed daily, the odds of forming kidney stones decreased by 13%.

Additionally, we observed that dietary zinc intake seemed to influence urinary zinc excretion. For each 1 mg increase in dietary zinc, there was a corresponding increase of 4.5 μg/dl in urine zinc levels. This suggests that higher zinc intake not only has potential benefits but also impacts how the body manages zinc through urine.

Overall, we found that lower dietary zinc intake is associated with a higher risk of calcium kidney stones in adolescents, indicating its possible role in prevention.
Read More
We explored the potential of zinc gluconate in treating calcium oxalate kidney stones, a common yet painful condition linked to high oxalate levels in the body. Our research involved administering zinc supplements to patients suffering from these stones, while also accounting for those who had received antibiotic treatments.

Through our clinical observations, we noticed that zinc appeared to boost the levels of beneficial bacteria in the gut that help break down oxalate, which is thought to contribute to stone formation. Specifically, we found that a lack of certain bacteria, notably Lactobacillus, along with low activity of the enzyme oxalate decarboxylase (OxDC), was connected to the development of kidney stones.

We also conducted tests on rats that developed more stones due to antibiotic use. Our findings suggested that zinc supplementation could enhance OxDC activity and promote Lactobacillus growth, both essential for better oxalate metabolism. Therefore, by focusing on the interplay between zinc, Lactobacillus, and OxDC, we propose a way that zinc might alleviate kidney stone symptoms by improving how oxalate is processed in the body.
Read More

Most Useful Reviews

7.5
Supports kidney health
3 people found this helpful
Zinc is vital for kidney health and hormone regulation. I take one tablet at 5 pm.
Read More
4
Prevent kidney stones
I advise taking it and consulting a doctor to prevent kidney stones.
Read More
2
Concern over kidney function
I’ve been taking this for quite some time, using half a tablet daily to maintain stamina and taste. My blood test indicated a decline in kidney function, making me reconsidercontinuing. I felt the effects, so I’ll switch to every two days.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
  • All Researches
We conducted a study to better understand how zinc affects the formation of kidney stones. In our investigation, we used rat models divided into various groups. Each group was treated differently with a plant-based herbal compound combined with ethylene glycol, which is known to promote crystal formation. Some of these groups also included zinc discs strategically placed in their bladders to see how well they could prevent crystal buildup.

Our findings revealed that rats receiving the herbal compound alongside ethylene glycol exhibited a reduced increase in crystal deposition around the zinc discs, especially at higher doses of the plant-based compound. However, the specific effects of zinc alone on crystal formation were challenging to isolate due to the combination treatments. It’s worth mentioning that while elevated urinary calcium levels were noted in some groups, we did not find a strong connection between oxalate levels and the doses administered.

Overall, the treatment seemed effective in lower doses of the herbal compound, with the most significant results appearing at a dosage of 0.332 ml taken three times a day. Unfortunately, we couldn't draw firm conclusions about zinc’s isolated impact on kidney stones, as its effect in the context of this study could not be fully determined due to the various influencing factors at play.
Read More
We explored the potential of zinc gluconate in treating calcium oxalate kidney stones, a common yet painful condition linked to high oxalate levels in the body. Our research involved administering zinc supplements to patients suffering from these stones, while also accounting for those who had received antibiotic treatments.

Through our clinical observations, we noticed that zinc appeared to boost the levels of beneficial bacteria in the gut that help break down oxalate, which is thought to contribute to stone formation. Specifically, we found that a lack of certain bacteria, notably Lactobacillus, along with low activity of the enzyme oxalate decarboxylase (OxDC), was connected to the development of kidney stones.

We also conducted tests on rats that developed more stones due to antibiotic use. Our findings suggested that zinc supplementation could enhance OxDC activity and promote Lactobacillus growth, both essential for better oxalate metabolism. Therefore, by focusing on the interplay between zinc, Lactobacillus, and OxDC, we propose a way that zinc might alleviate kidney stone symptoms by improving how oxalate is processed in the body.
Read More
7
Evaluating kidney stone treatments
We conducted a case-control study to explore the potential benefits of a nutritional supplement, Fagolitos plus®, which contains zinc, alongside extracorporeal shock wave lithotripsy for treating kidney stones. Our study involved 88 patients divided into two groups: one group received the supplement with their lithotripsy treatment, while the other had the procedure alone.

The goal was to assess whether combining Fagolitos plus® with lithotripsy would lead to better fragmentation of kidney stones. We looked at several factors, including the size and location of the stones, as well as any adverse effects from the supplement. The results indicated that the use of Fagolitos plus® alongside lithotripsy may enhance the effectiveness of this popular kidney stone treatment, although further clinical trials are necessary to verify these findings.

Importantly, while zinc is part of the formulation of Fagolitos plus®, the specific influence of zinc alone on kidney stones remains unclear because our study emphasized the combination treatment approach. We see this as a promising avenue for future research to better understand the role of zinc and similar compounds in managing kidney stones.
Read More
7
Zinc's role in kidney stones
We investigated how different forms of zinc intake—dietary, supplemental, and serum levels—might connect to the prevalence of kidney stones in adults. By analyzing data from the National Health and Nutrition Examination Survey (NHANES) collected over nearly a decade, we uncovered some interesting patterns.

Our findings revealed that dietary zinc intake appeared to be linked to a lower likelihood of developing kidney stones. In fact, for every increase in daily zinc intake, the odds of having kidney stones decreased. We noted that this relationship was particularly strong among women and individuals who were classified as overweight or obese.

Interestingly, while dietary zinc and serum zinc levels were inversely associated with kidney stones, we found no significant connection with supplemental zinc intake. This suggests that getting zinc from food sources may be more beneficial for kidney stone prevention than taking zinc supplements.

Overall, while our analysis highlights a potential protective effect of dietary zinc and serum zinc levels against kidney stones, it also points out the need for more thorough research to fully understand these relationships.
Read More
We examined the link between dietary zinc intake and the occurrence of calcium kidney stones among adolescents. To do this, we conducted a nested case-control study involving 30 teenagers aged 12 to 18 who had their first calcium-based kidney stone and matched them with 30 healthy controls based on age, sex, race, and enrollment month.

What we found was quite revealing. The teenagers who developed kidney stones were consuming less daily zinc—around 8.1 mg—compared to their healthy counterparts, who averaged 10 mg. Furthermore, the intake for both boys and girls in the kidney stone group fell below the recommended levels set by health authorities. Even more interestingly, we discovered that for every additional 1 mg of zinc consumed daily, the odds of forming kidney stones decreased by 13%.

Additionally, we observed that dietary zinc intake seemed to influence urinary zinc excretion. For each 1 mg increase in dietary zinc, there was a corresponding increase of 4.5 μg/dl in urine zinc levels. This suggests that higher zinc intake not only has potential benefits but also impacts how the body manages zinc through urine.

Overall, we found that lower dietary zinc intake is associated with a higher risk of calcium kidney stones in adolescents, indicating its possible role in prevention.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 4 Reviews
7.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Supports kidney health
3 people found this helpful
Zinc is vital for kidney health and hormone regulation. I take one tablet at 5 pm.
Read More
4
Prevent kidney stones
I advise taking it and consulting a doctor to prevent kidney stones.
Read More
2
Concern over kidney function
I’ve been taking this for quite some time, using half a tablet daily to maintain stamina and taste. My blood test indicated a decline in kidney function, making me reconsidercontinuing. I felt the effects, so I’ll switch to every two days.
Read More
0
Manage dosage carefully
3 people found this helpful
The product contains a very high dose and elevated my pressure, so I suggest splitting the pill into quarters, as it affects the liver and kidneys!
Read More

Frequently Asked Questions

7.5
Supports kidney health
3 people found this helpful
Zinc is vital for kidney health and hormone regulation. I take one tablet at 5 pm.
2
Concern over kidney function
I’ve been taking this for quite some time, using half a tablet daily to maintain stamina and taste. My blood test indicated a decline in kidney function, making me reconsidercontinuing. I felt the effects, so I’ll switch to every two days.
0
Manage dosage carefully
3 people found this helpful
The product contains a very high dose and elevated my pressure, so I suggest splitting the pill into quarters, as it affects the liver and kidneys!
4
Prevent kidney stones
I advise taking it and consulting a doctor to prevent kidney stones.
We explored the potential of zinc gluconate in treating calcium oxalate kidney stones, a common yet painful condition linked to high oxalate levels in the body. Our research involved administering zinc supplements to patients suffering from these stones, while also accounting for those who had received antibiotic treatments.

Through our clinical observations, we noticed that zinc appeared to boost the levels of beneficial bacteria in the gut that help break down oxalate, which is thought to contribute to stone formation. Specifically, we found that a lack of certain bacteria, notably Lactobacillus, along with low activity of the enzyme oxalate decarboxylase (OxDC), was connected to the development of kidney stones.

We also conducted tests on rats that developed more stones due to antibiotic use. Our findings suggested that zinc supplementation could enhance OxDC activity and promote Lactobacillus growth, both essential for better oxalate metabolism. Therefore, by focusing on the interplay between zinc, Lactobacillus, and OxDC, we propose a way that zinc might alleviate kidney stone symptoms by improving how oxalate is processed in the body.
7
Evaluating kidney stone treatments
We conducted a case-control study to explore the potential benefits of a nutritional supplement, Fagolitos plus®, which contains zinc, alongside extracorporeal shock wave lithotripsy for treating kidney stones. Our study involved 88 patients divided into two groups: one group received the supplement with their lithotripsy treatment, while the other had the procedure alone.

The goal was to assess whether combining Fagolitos plus® with lithotripsy would lead to better fragmentation of kidney stones. We looked at several factors, including the size and location of the stones, as well as any adverse effects from the supplement. The results indicated that the use of Fagolitos plus® alongside lithotripsy may enhance the effectiveness of this popular kidney stone treatment, although further clinical trials are necessary to verify these findings.

Importantly, while zinc is part of the formulation of Fagolitos plus®, the specific influence of zinc alone on kidney stones remains unclear because our study emphasized the combination treatment approach. We see this as a promising avenue for future research to better understand the role of zinc and similar compounds in managing kidney stones.
We examined the link between dietary zinc intake and the occurrence of calcium kidney stones among adolescents. To do this, we conducted a nested case-control study involving 30 teenagers aged 12 to 18 who had their first calcium-based kidney stone and matched them with 30 healthy controls based on age, sex, race, and enrollment month.

What we found was quite revealing. The teenagers who developed kidney stones were consuming less daily zinc—around 8.1 mg—compared to their healthy counterparts, who averaged 10 mg. Furthermore, the intake for both boys and girls in the kidney stone group fell below the recommended levels set by health authorities. Even more interestingly, we discovered that for every additional 1 mg of zinc consumed daily, the odds of forming kidney stones decreased by 13%.

Additionally, we observed that dietary zinc intake seemed to influence urinary zinc excretion. For each 1 mg increase in dietary zinc, there was a corresponding increase of 4.5 μg/dl in urine zinc levels. This suggests that higher zinc intake not only has potential benefits but also impacts how the body manages zinc through urine.

Overall, we found that lower dietary zinc intake is associated with a higher risk of calcium kidney stones in adolescents, indicating its possible role in prevention.
7
Zinc's role in kidney stones
We investigated how different forms of zinc intake—dietary, supplemental, and serum levels—might connect to the prevalence of kidney stones in adults. By analyzing data from the National Health and Nutrition Examination Survey (NHANES) collected over nearly a decade, we uncovered some interesting patterns.

Our findings revealed that dietary zinc intake appeared to be linked to a lower likelihood of developing kidney stones. In fact, for every increase in daily zinc intake, the odds of having kidney stones decreased. We noted that this relationship was particularly strong among women and individuals who were classified as overweight or obese.

Interestingly, while dietary zinc and serum zinc levels were inversely associated with kidney stones, we found no significant connection with supplemental zinc intake. This suggests that getting zinc from food sources may be more beneficial for kidney stone prevention than taking zinc supplements.

Overall, while our analysis highlights a potential protective effect of dietary zinc and serum zinc levels against kidney stones, it also points out the need for more thorough research to fully understand these relationships.
7
Zinc intake linked to kidney stones
We aimed to understand how dietary zinc intake might be related to kidney stone disease. By analyzing data from The Third National Health and Nutrition Examination Survey (NHANES III), we took a close look at a substantial group of adults to see if there was a noteworthy connection between their zinc intake and the prevalence of kidney stones as reported by participants themselves.

Our analysis included over 15,000 individuals aged 18 and older, revealing that 710 had a history of kidney stones. It's interesting to note that stone formers generally had a higher dietary zinc intake compared to those who had never experienced stones. However, this wasn’t deemed statistically significant.

Yet, when we dug deeper using multivariate logistic regression analysis, we found that higher dietary zinc intake was indeed associated with an increased risk of kidney stone disease. Specifically, the odds increased significantly when comparing those with a high intake (more than 15 mg/day) to those with lower intake (under 7 mg/day).

While our findings suggest that higher dietary zinc may elevate the risk of developing kidney stones, it’s important to clarify that this is an association, not a definitive cause. Therefore, more prospective studies are needed to fully unravel how zinc intake influences kidney stone formation.

References

  1. Güzel R, Erïhan İB, Özaydin İ, Aydin U, Bağcioğlu M, et al. Dose-dependant preventive effect of a herbal compound on crystal formation in rat model. Arch Ital Urol Androl. 2023;95:11114. 10.4081/aiua.2023.11114
  2. Wu F, Cheng Y, Zhou J, Liu X, Lin R, et al. Zn regulates human oxalate metabolism by manipulating oxalate decarboxylase to treat calcium oxalate stones. Int J Biol Macromol. 2023;234:123320. 10.1016/j.ijbiomac.2023.123320
  3. Morales-Martínez A, Melgarejo-Segura MT, Cano-García MDC, Gutiérrez-Tejero F, Arrabal-Martín M, et al. [Assessment of radiopaque kidney stone treatment: Combination of extracorporeal shock wave lithotripsy and Fagolitos Plus®. Preliminary case control description.]. Arch Esp Urol. 2021;74:489.
  4. Sun Y, Wang Y, Wang D, Zhou Q. Dietary zinc intake, supplemental zinc intake and serum zinc levels and the prevalence of kidney stones in adults. J Trace Elem Med Biol. 2020;57:126410. 10.1016/j.jtemb.2019.126410
  5. Tasian GE, Ross ME, Song L, Grundmeier RW, Massey J, et al. Dietary Zinc and Incident Calcium Kidney Stones in Adolescence. J Urol. 2017;197:1342. 10.1016/j.juro.2016.11.096
  6. Chi T, Kim MS, Lang S, Bose N, Kahn A, et al. A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease. PLoS One. 2015;10:e0124150. 10.1371/journal.pone.0124150
  7. Tang J, McFann K, Chonchol M. Dietary zinc intake and kidney stone formation: evaluation of NHANES III. Am J Nephrol. 2012;36:549. 10.1159/000345550
  8. Grases F, Garcia-Gonzalez R, Torres JJ, Llobera A. Effects of phytic acid on renal stone formation in rats. Scand J Urol Nephrol. 1998;32:261.
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